Jointly Depleting Glutathione Based on Self‐Assembled Nanomicelles for Enhancing Photodynamic Therapy

Author:

Wu Jingxi1,Shang Jingjing1,An Jing1,Chen Wenlong1,Hong Gaobo1,Hou Haoran1,Zheng Wen‐Heng2,Song Fengling13ORCID,Peng Xiaojun1

Affiliation:

1. State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology Dalian 116024 China

2. Department of Interventional Therapy Cancer Hospital of Dalian University of Technology Liaoning Cancer Hospital and Institute Shenyang 110042 China

3. Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary Science Shandong University Qingdao 266237 China

Abstract

AbstractPhotodynamic therapy (PDT) is one common ROS‐generating therapeutic method with high tumor selectivity and low side effects. But the GSH‐upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self‐assembly method from GSH‐activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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