Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

Author:

Borutzki Yasmin123ORCID,Skos Lukas23ORCID,Gerner Christopher24ORCID,Meier‐Menches Samuel M.124ORCID

Affiliation:

1. Institute of Inorganic Chemistry Faculty of Chemistry University of Vienna 1090 Vienna Austria

2. Department of Analytical Chemistry Faculty of Chemistry University of Vienna 1090 Vienna Austria

3. Doctoral School of Chemistry University of Vienna 1090 Vienna Austria

4. Joint Metabolome Facility University of Vienna and Medical University Vienna 1090 Vienna Austria

Abstract

AbstractDuring recent years, accumulating evidence suggested that metal‐based candidate drugs are promising modulators of cytoskeletal and cytoskeleton‐associated proteins. This was substantiated by the identification and validation of actin, vimentin and plectin as targets of distinct ruthenium(II)‐ and platinum(II)‐based modulators. Despite this, structural information about molecular interaction is scarcely available. Here, we compile the scattered reports about metal‐based candidate molecules that influence the cytoskeleton, its associated proteins and explore their potential to interfere in cancer‐related processes, including proliferation, invasion and the epithelial‐to‐mesenchymal transition. Advances in this field depend crucially on determining binding sites and on gaining comprehensive insight into molecular drug‐target interactions. These are key steps towards establishing yet elusive structure‐activity relationships.

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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