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Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach

  • Published:2018-01-29 Issue:4 Volume:35 Page:331-341
  • ISSN:0749-503X
  • Container-title:Yeast
  • language:en
  • Short-container-title:Yeast

Author:

de Ruijter Jorg C.1,Koskela Essi V.1,Nandania Jatin2,Frey Alexander D.1ORCID,Velagapudi Vidya2

Affiliation:

1. Department of Bioproducts and Biosystems, School of Chemical Engineering; Aalto University; Finland, Kemistintie 1 02150 Espoo Finland

2. Metabolomics Unit, Institute for Molecular Medicine Finland FIMM; University of Helsinki; Tukholmankatu 8U Helsinki Finland

Publisher

Wiley

Subject

Genetics,Applied Microbiology and Biotechnology,Biochemistry,Bioengineering,Biotechnology

Reference27 articles.

1. Pathway activity profiling (papi): From the metabolite profile to the metabolic pathway activity;Aggio;Bioinformatics,2010

2. Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae;Coleman;Journal of Biological Chemistry,2001

3. Competition between glutathione and protein thiols for disulphide-bond formation;Cuozzo;Nature Cell Biology,1999

4. Enhancing antibody folding and secretion by tailoring the Saccharomyces cerevisiae endoplasmic reticulum;Ruijter;Microbial Cell Factories,2016

5. Genome-scale modeling of the protein secretory machinery in yeast;Feizi;PLoS One,2013
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