Affiliation:
1. Department of Radiation Oncology National Cancer Center Hospital East Kashiwa Japan
2. Department of Radiological Technology National Cancer Center Hospital East Kashiwa Japan
3. Department of Head and Neck Surgery National Cancer Center Hospital East Kashiwa Japan
Abstract
AbstractBackgroundWe evaluated clinical and dosimetric outcomes of radiotherapy using two anterior oblique portals (AOP), to reduce the dose to the bilateral internal carotid arteries (CAs) and pharyngeal constrictor muscle (PCM) during early‐stage glottic cancer (ESGC) treatment.MethodsWe identified patients with ESGC who underwent definitive radiotherapy between June 2014 and May 2020.ResultsAmong the 66 patients, 32 (48%) underwent radiotherapy using AOP, and the remaining underwent typical radiotherapy using parallel opposed lateral portals (POLP). The median follow‐up duration was 53 months. No significant differences were observed in the 5‐year local failure (0%/9.4%), progression‐free survival (90.6%/90.8%), and overall survival (90.6%/91.0%) rates between the two groups. The grade ≥2 acute mucositis incidence rate was significantly lower in the AOP group (44%/85%). Radiotherapy using AOP maintained an adequate dose coverage to the target while markedly reducing the CAs and PCM doses.ConclusionRadiotherapy with AOP resulted in favorable clinical and dosimetric outcomes.
Funder
Japan Agency for Medical Research and Development