Author:
Fowler Bruce A.,Madden Emily F.,Chou Selene
Abstract
AbstractThe production of arsenic usually occurs as a by‐product of smelting of copper, lead, or gold ores. It has been estimated that the atmospheric flux of arsenic was ∼73,540 tons/year, 60% of which was of natural origin, and the rest was derived from anthropogenic sources. This element is used for a variety of industries including glass manufacturing, wood preservatives, metal alloys, pesticides, and in the manufacture of semiconductors as a dopant for silicon‐based semiconductors or the production of III–V semiconductors such gallium arsenide and indium arsenide.Fowler's solution (potassium arsenite‐As3+) had been used in the past to treat a variety of clinical illnesses such as leukemia and skin disorders such as psoriasis and bronchial asthma but was supplanted by more modern chemotherapeutic agents during the past 20 years. More recently, As3+has been effectively used to treat acute promyelocytic leukemia.Human exposure to inorganic arsenic may occur via air, food, and water. Persons consuming seafood generally have higher total intakes of arsenic, but the chemical forms of arsenic are primarily arsenobetaine and other methylated species of relatively low toxic potential.Arsenic is a general systemic poison whose toxic and medicinal properties have been known for several thousand years. The carcinogenic properties of inorganic arsenicals in humans have been known for several hundred years.Sb as an element is a brittle, flaky, crystalline (hexagonal) silver‐white metal. It does not react with air at room temperature but burns brightly when heated and forms white fumes. It is a poor conductor of electricity and heat. Antimony occurs in tri‐ (+3) and pentavalent (+5) compounds and is found in the Earth's crust mostly associated with sulfur as stibnite and in ores associated with arsenic. Antimony is a group VA element of the periodic table and it has many of the same chemical and biological properties as the element arsenic.Stibine gas is odorless. Exposure to antimony at high levels may result in a variety of adverse health effects. For example, breathing high levels of antimony and some of its compounds can irritate the eyes and lungs and can cause problems with the heart, lungs, and stomach.Historically, antimony compounds were used as emetics and expectorants. Recently, antimony compounds, such as tartar emetic and sodium stibogluconate, are used as anthelmintic and antiprotozoal drugs in treating parasitic diseases and infections. It plays no role in nutrition and is a nonessential element.Bismuth is a brittle, white, crystalline metal that has a pinkish tint. It is the most diamagnetic of all metals, and its thermal conductivity is lower than that of any metal except mercury. In addition, bismuth has high electrical resistance and the highest Hall effect of any metal. Inorganic salts of bismuth are poorly water soluble; solubility is influenced by the acidity of the medium and the presence of additional certain compounds containing sulfhydryl or hydroxyl groups. Bismuth belongs to the group VA of the periodic table together with arsenic and antimony, and forms compounds in the +3 and +5 oxidation states. Bismuth occurs in the native form; however, it is found largely in nature in minerals such as bismite, bismuthinite, and bismutite and is usually associated with sulfide ores of lead and copper and tin dioxide.Human exposure to bismuth and bismuth compounds is quite limited, except for its use in medicine where it has been prescribed for more than a century. Occupational and environmental exposure to bismuth and its toxicological significance are still unknown.
Reference468 articles.
1. International Agency for Research on Cancer (IARC) 1980 IARC Lyon France 39 141
2. World Health Organization (WHO) Environmental Health Criteria 224: Arsenic and Arsenic Compounds 2001 WHO Geneva 28 33
3. Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients
4. Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide
5. National Research Council (NRC) 1999 National Academy Press Washington DC 177 192
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献