Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

Author:

Stelma Tamara1,Chi Alicia1,van der Watt Pauline J.1,Verrico Annalisa2,Lavia Patrizia2,Leaner Virna D.1

Affiliation:

1. Division of Medical Biochemistry, Department of Integrative Biomedical Sciences; SAMRC/UCT Gynaecological Cancer Research Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town; Cape Town South Africa

2. Institute of Molecular Biology and Pathology, National Research Council of Italy, C/O University of Roma “La Sapienza”; Rome Italy

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Genetics,Molecular Biology,Biochemistry

Reference118 articles.

1. Importins and exportins regulating allergic immune responses;Aggarwal;Mediators Inflamm.,2014

2. Molecular basis for specificity of nuclear import and prediction of nuclear localization;Marfori;Biochim. Biophys. Acta,2011

3. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation;Watt;Int. J. Cancer,2009

4. Upregulation of KPNbeta1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis;Zhu;Tumour Biol.,2015

5. Hyper-dependence of breast cancer cell types on the nuclear transporter Importin beta1;Kuusisto;Biochim. Biophys. Acta,2015

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