Affiliation:
1. Department of Burns and Plastic Surgery Changzhou Wujin People's Hospital Changzhou China
2. Department of Plastic and Reconstructive Surgery, Xijing Hospital Fourth Military Medical University Xi'an China
3. Shaanxi Provincial Key Laboratory of Clinic Genetics Fourth Military Medical University Xi'an China
Abstract
AbstractAimWe aimed to explore the impact of DNA methylation alterations on the DNA damage response (DDR) in melanoma prognosis and immunity.Material & methodsDifferent melanoma cohorts with molecular and clinical data were included.ResultsHierarchical clustering utilizing different combinations of DDR‐relevant CpGs yielded distinct melanoma subtypes, which were characteristic of different prognoses, transcriptional function profiles of DDR, and immunity and immunotherapy responses but were associated with similar tumor mutation burdens. We then constructed and validated a clinically applicable 4‐CpG risk‐score signature for predicting survival and immunotherapy response.ConclusionOur study describes the close interrelationship among DNA methylation, DDR machinery, local tumor immune status, melanoma prognosis, and immunotherapy response.