Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Author:

Su Linzhu1,Li Yuanfeng1,Liu Yong1ORCID,An Yingli1,Shi Linqi1ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials Ministry of Education Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China

Abstract

AbstractBacterial infection is becoming the biggest threat to human health. The scenario is partly due to the ineffectiveness of the conventional antibiotic treatments against the emergence of multidrug‐resistant bacteria and partly due to the bacteria living in biofilms or cells. Adaptive biomaterials can change their physicochemical properties in the microenvironment of bacterial infection, thereby facilitating either their interactions with bacteria or drug release. The trends in treating bacterial infections using adaptive biomaterials‐based systems are flourishing and generate innumerous possibility to design novel antimicrobial therapeutics. This feature article aims to summarize the recent developments in the formulations, mechanisms, and advances of adaptive materials in bacterial infection diagnosis, contact killing of bacteria, and antimicrobial drug delivery. Also, the challenges and limitations of current antimicrobial treatments based on adaptive materials and their clinical and industrial future prospects are discussed.

Funder

Innovative Research Group Project of the National Natural Science Foundation of China

Publisher

Wiley

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