Affiliation:
1. Department of Otolaryngology Head and Neck Surgery Peking University Third Hospital Beijing 100191 P. R. China
2. Department of Pharmacy Peking University Third Hospital Beijing 100191 P. R. China
3. CAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China
Abstract
AbstractAllergic rhinitis, as the most common type of rhinitis, has become a global health problem. At present, oral/intranasal administration of H1‐antihistamines and corticosteroids is considered to be the main therapeutic method for allergic rhinitis. However, the local bioavailability of the drug is low due to the systemic effect of drugs and nasal mucociliary clearance. More recently, a hydrogel‐based intranasal delivery system (HIDS) is proposed and gradually developed as an emerging strategy for allergic rhinitis treatment by extending the residence time of drugs in a controlled manner. This review aims to highlight the advances in HIDS for allergic rhinitis treatment. The designs and therapeutic effect of the existing HIDS in the nasal microenvironment are described in detail. This review also provides a perspective on the future opportunities and developments of HIDS. Despite its nascent status, the future clinical and translational applications of HIDS can have a transformative impact on improving the treatment of chronic inflammation in the nasal cavity.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Subject
Pharmacology (medical),Biochemistry (medical),Genetics (clinical),Pharmaceutical Science,Pharmacology,Medicine (miscellaneous)