Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein-Reference-Cited by-同舟云学术

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

Published:2022-09-10 Issue:4 Volume:3 Page:
ISSN:2688-2663
Container-title:MedComm
language:en
Short-container-title:MedComm

Author:

Ye Fang¹²,Wong Thian‐Sze¹,Chen Geng¹,Zhang Zhiyi¹,Zhang Binghao¹,Gan Shiyi¹,Gao Wei¹,Li Jiancheng³,Wu Zhangsong¹,Pan Xin¹,Du Yang¹²

Affiliation:

1. Kobilka Institute of Innovative Drug Discovery Shenzhen Key Laboratory of Steroid Drug Discovery and Development School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong China

2. The Chinese University of Hong Kong Shenzhen Futian Biomedical Innovation R&D Center Shenzhen Guangdong China

3. Instrumental Analysis Center Shenzhen University Shenzhen Guangdong China

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mco2.159

Reference27 articles.

1. G Protein–Coupled Receptor Deorphanizations

2. The GPR17 Receptor—A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis

3. Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

4. The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

5. The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules

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