Affiliation:
1. State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases School of Chemical Engineering Sichuan University Chengdu 610065 China
2. Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu 610041 China
3. State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China
4. Department of Chemistry Washington State University Pullman WA 99164 USA
5. Department of Mechanical Engineering The University of Hong Kong Hong Kong 999077 China
Abstract
AbstractPhotodynamic therapy (PDT) acts as a powerful weapon against infectious diseases for its enormous antimicrobial activity that quickly elicits storms of reactive oxygen species (ROS). Nevertheless, redundant ROS during treatment inevitably bring detriments in revascularization. To address this dilemma, an innovative P‐N bio‐heterojunction (bio‐HJ) material consisting of p‐type copper sulfide (p‐CuS), n‐type bismuth sulfide (n‐Bi2S3), and lactate oxidase (LOx) for effective treatment of recalcitrant infectious wounds by promoting angiogenesis is devised. LOx exhausts lactic acid accumulated in infection environment and converts it to hydrogen peroxide (H2O2), which subsequently yields bactericidal hydroxyl radicals (·OH) via Fenton‐like reactions. Ultimately, the P‐N bio‐HJs exert synergistic photothermal, photodynamic, and chemodynamic effects for rapid bacterial annihilation. Moreover, in vitro and RNA‐seq analyses reveal that the crafted bio‐HJs dramatically expedite the proliferation of L929 cells and promote angiogenesis by up‐regulating angiogenic gene expression in hypoxia‐inducible factor‐1 (HIF‐1) signaling pathway, which may ascribe to the evolution of H2S in response to the infection microenvironment. Critically, results of in vivo experiments have authenticated that the bio‐HJs significantly boost healing rates of full‐thickness wounds by slaughtering bacteria, elevating angiogenesis, and promoting cytothesis. As envisioned, this work furnishes a novel tactic for the effective treatment of bacteria‐invaded wound using H2S‐liberating P‐N bio‐HJs.
Funder
National Natural Science Foundation of China
Key Research and Development Program of Sichuan Province
State Key Laboratory of Polymer Materials Engineering
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
4 articles.
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