Affiliation:
1. Institute of Urology The Third Affiliated Hospital of Shenzhen University Shenzhen 518000 P. R. China
2. Shenzhen Following Precision Medical Research Institute Luohu Hospital Group Shenzhen 518000 P. R. China
3. Andrew and Peggy Cherng Department of Medical Engineering California Institute of Technology Pasadena CA 91125 USA
4. School of Biomedical Engineering Health Science Centre Shenzhen University Shenzhen 518060 P. R. China
5. South China Hospital Health Science Center Shenzhen University Shenzhen 518116 P. R. China
Abstract
AbstractMotile microrobots open a new realm for disease treatment. However, the concerns of possible immune elimination, targeted capability and limited therapeutic avenue of microrobots constrain its practical biomedical applications. Herein, a biogenic macrophage‐based microrobot loaded with magnetic nanoparticles and bioengineered bacterial outer membrane vesicles (OMVs), capable of magnetic propulsion, tumor targeting, and multimodal cancer therapy is reported. Such cell robots preserve intrinsic properties of macrophages for tumor suppression and targeting, and bioengineered OMVs for antitumor immune regulation and fused anticancer peptides. Cell robots display efficient magnetic propulsion and directional migration in the confined space. In vivo tests show that cell robots can accumulate at the tumor site upon magnetic manipulation, coupling with tumor tropism of macrophages to greatly improve the efficacy of its multimodal therapy, including tumor inhibition of macrophages, immune stimulation, and antitumor peptides of OMVs. This technology offers an attractive avenue to design intelligent medical microrobots with remote manipulation and multifunctional therapy capabilities for practical precision treatment.
Funder
China Postdoctoral Science Foundation
Science, Technology and Innovation Commission of Shenzhen Municipality
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
3 articles.
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