Affiliation:
1. Department of Endocrinology Nanjing Drum Tower Hospital Medical School Nanjing University Nanjing 210008 P. R. China
2. Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. China
3. Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center PLA General Hospital and PLA Medical College 28 Fu Xing Road Beijing 100853 P. R. China
Abstract
AbstractWound healing, known as a fundamental healthcare issue worldwide, has been attracting great attention from researchers. Here, novel bioactive gellan gum microfibers loaded with antibacterial peptides (ABPs) and vascular endothelial growth factor (VEGF) are proposed for wound healing by using microfluidic spinning. Benefitting from the high controllability of microfluidics, bioactive microfibers with uniform morphologies are obtained. The loaded ABPs are demonstrated to effectively act on bacteria at the wound site, reducing the risk of bacterial infection. Besides, sustained release of VEGF from microfibers helps to accelerate angiogenesis and further promote wound healing. The practical value of woven bioactive microfibers is demonstrated via animal experiments, where the wound healing process is greatly facilitated because of the excellent circulation of air and nutritious substances. Featured with the above properties, it is believed that the novel bioactive gellan gum microfibers would have a remarkable effect in the field of biomedical application, especially in promoting wound healing.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Shenzhen Fundamental Research Program
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry