Shape Anisotropy‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

Author:

Nigam Saumya12,Mohapatra Jeotikanta3,Makela Ashley V.45,Hayat Hanaan12,Rodriguez Jessi Mercedes126,Sun Aixia12,Kenyon Elizabeth12,Redman Nathan A.45,Spence Dana45,Jabin George3,Gu Bin7,Ashry Mohamed12,Sempere Lorenzo F.12,Mitra Arijit8,Li Jinxing45,Chen Jiahui9,Wei Guo‐Wei91011,Bolin Steven12,Etchebarne Brett13,Liu J. Ping3,Contag Christopher H.4514,Wang Ping12

Affiliation:

1. Precision Health Program Michigan State University East Lansing MI 48824 USA

2. Department of Radiology College of Human Medicine Michigan State University East Lansing MI 48824 USA

3. Department of Physics The University of Texas at Arlington Arlington TX 76019 USA

4. Institute for Quantitative Health Science and Engineering (IQ) Michigan State University East Lansing MI 48824 USA

5. Department of Biomedical Engineering College of Engineering Michigan State University East Lansing MI 48824 USA

6. Human Biology Program College of Natural Science Michigan State University East Lansing MI 48824 USA

7. Department of Obstetrics Gynecology and Reproductive Sciences College of Human Medicine Michigan State University East Lansing MI 48824 USA

8. Department of Materials Science and Engineering National Cheng Kung University Tainan City 701 Taiwan

9. Department of Mathematics College of Natural Science Michigan State U niversity East Lansing MI 48824 USA

10. Department of Electrical and Computer Engineering College of Engineering Michigan State University East Lansing MI 48824 USA

11. Department of Biochemistry and Molecular Biology College of Natural Science Michigan State University East Lansing MI 48824 USA

12. Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing MI 48824 USA

13. Osteopathic Medical Specialties College of Osteopathic Medicine Michigan State University East Lansing MI 48824 USA

14. Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI 48824 USA

Abstract

AbstractCaused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal‐to‐noise ratios to lung imaging for the development of new theranostic approaches for respiratory diseases. Advances in MPI tracers would offer additional improvements and increase the potential for clinical translation of MPI. Here, a high‐performance nanotracer based on shape anisotropy of magnetic nanoparticles is developed and its use in MPI imaging of the lung is demonstrated. Shape anisotropy proves to be a critical parameter for increasing signal intensity and resolution and exceeding those properties of conventional spherical nanoparticles. The 0D nanoparticles exhibit a 2‐fold increase, while the 1D nanorods have a > 5‐fold increase in signal intensity when compared to VivoTrax. Newly designed 1D nanorods displayed high signal intensities and excellent resolution in lung images. A spatiotemporal lung imaging study in mice revealed that this tracer offers new opportunities for monitoring disease and guiding intervention.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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