Affiliation:
1. Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 China
2. Tumor Pathology Research Group & Department of Pathology Institute of Basic Disease Sciences & School of Basic Medical Sciences Xiangnan University Chenzhou Hunan 423000 China
3. State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China
4. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education College of Chemistry and Chemical Engineering Hainan Normal University Haikou Hainan 571158 China
Abstract
AbstractEffectively interfering energy metabolism in tumor cells and simultaneously activating the in vivo immune system to perform immune attacks are meaningful for tumor treatment. However, precisely targeted therapy is still a huge challenge. Herein, a mitochondrial‐targeting phototheranostic system, FE‐T nanoparticles (FE‐T NPs) are developed to damage mitochondria in tumor cells and change the tumor immunosuppressive microenvironment. FE‐T NPs are engineered by encapsulating the near‐infrared (NIR) absorbed photosensitizer IR‐FE‐TPP within amphiphilic copolymer DSPE‐SS‐PEG‐COOH for high‐performing with simultaneous mitochondrial‐targeting, near‐infrared II (NIR‐II) fluorescence imaging, and synchronous photothermal therapy (PTT) /photodynamic therapy (PDT) /immune therapy (IMT). In tumor treatment, the disulfide in the copolymer can be cleaved by excess intracellular glutathione (GSH) to release IR‐FE‐TPP and accumulate in mitochondria. After 808 nm irradiation, the mitochondrial localization of FE‐T NPs generated reactive oxygen species (ROS), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (ICD). Notably, in situ enhanced PDT/PTT in vivo via mitochondrial‐targeting with FE‐T NPs boosts highly efficient ICD toward excellent antitumor immune response. FE‐T NPs provide an effective mitochondrial‐targeting phototheranostic nanoplatform for imaging‐guided tumor therapy.
Funder
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
7 articles.
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