Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment

Author:

Suran Swathi1,Kamyar Negin1,Huang Kun1,Foroutan Farzad1,Balakrishna Pillai Premlal1,Liu Xuzhao2,Vaughan John3,Wilson Darren3,Day Philip J.4,Nair Rahul R.1ORCID

Affiliation:

1. National Graphene Institute & Department of Chemical Engineering University of Manchester Manchester M13 9PL UK

2. Department of Materials University of Manchester/Photon Science Institute University of Manchester Manchester M13 9PL UK

3. T. J. Smith and Nephew Limited 101 Hessle Road Hull HU3 2BN UK

4. Manchester Institute of Biotechnology & Division of Evolution Infection & Genomic Sciences University of Manchester Manchester M13 9PL UK

Abstract

AbstractSilver has long been recognized for its potent antimicrobial properties, but achieving a slow and longer‐term delivery of silver ions presents significant challenges. Previous efforts to control silver ion dosages have struggled to sustain release for extended periods in biomimetic environments, especially in the presence of complex proteins. This challenge is underscored by the absence of technology for sustaining antimicrobial activity, especially in the context of orthopedic implants where long‐term efficacy, extending beyond 7 days, is essential. In this study, the tunable, slow, and longer‐term release of silver ions from the two‐dimensional (2D) nanocapillaries of graphene oxide (GO) laminates incorporated with silver ions (Ag‐GO) for antimicrobial applications are successfully demonstrated. To closely mimic a physiologically relevant serum‐based environment, a novel in vitro study model using 100% fetal bovine serum (FBS) is introduced as the test medium for microbiology, biocompatibility, and bioactivity studies. To emulate fluid circulation in a physiological environment, the in vitro studies are challenged with serum exchange protocols on different days. The findings show that the Ag‐GO coating can sustainably release silver ions at a minimum dosage of 10 µg cm−2 day−1, providing an effective and sustained antimicrobial barrier for over ten days.

Funder

Engineering and Physical Sciences Research Council

European Research Council

Graphene Flagship

Leverhulme Trust

Royal Statistical Society

Publisher

Wiley

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