Affiliation:
1. The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School Nanjing University Nanjing China
2. Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School Nanjing University Nanjing China
3. Department of Breast Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital Nanjing China
Abstract
AbstractBackgroundPANoptosis is a novel form of programmed cell death (PCD) found in 2019 that is regulated by the PANoptosome. PANoptosis combines essential features of pyroptosis, apoptosis, and necroptosis, forming a “death triangle” of cells. While apoptosis, pyroptosis, and necroptosis have been extensively studied for their roles in human inflammatory diseases and many other clinical conditions, historically they were considered as independent processes. However, emerging evidence indicates that these PCDs exhibit cross talk and interactions, resulting in the development of the concept of PANoptosis.MethodsIn this review, we offer a concise summary of the fundamental mechanisms of apoptosis, pyroptosis, and necroptosis. We subsequently introduce the notion of PANoptosis and detail the assembly mechanism of the PANoptosome complex which is responsible for inducing cell death. We also describe some regulatory networks of PANoptosis.ResultsPANoptosis now has been associated with various human diseases including cancer. Although the exact function of PANoptosis in each tumor is not fully understood, it represents a prospective avenue for cancer therapy, offering promise for advancements in cancer therapy.ConclusionsIn the future, in‐depth study of PANoptosis will continue to help us in understanding the fundamental processes underlying cell death and provide scientific support for cancer research.
Funder
Fundamental Research Funds for the Central Universities
Nanjing Medical Science and Technique Development Foundation
National Natural Science Foundation of China
Science Fund for Distinguished Young Scholars of Jiangsu Province
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology