The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism
Author:
Affiliation:
1. National Institute for Public Health and the Environment (RIVM); 3721 MA Bilthoven The Netherlands
2. Department of Toxicogenomics; MaastrichtUniversity; POBOX 616 6200 MD Maastricht The Netherlands
Funder
Netherlands Genomics Initiative Organization for Research (NOW)
Publisher
Wiley
Subject
Toxicology
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3. In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxigenomics;Baken;Toxicology,2007
4. Rapamycin blocks the Phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation;Beretta;EMBO J.,1996
5. Control of p70 S6 kinase by kinase activity of FRAP in vivo;Brown;Nature,2002
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1. Tributyltin Oxide Exposure During in vitro Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs;Frontiers in Cell and Developmental Biology;2021-06-28
2. Tributyltin oxide exposure impairs mouse oocyte maturation and its possible mechanisms;Journal of Cellular Biochemistry;2018-09-07
3. Protein phosphorylation profiling identifies potential mechanisms for direct immunotoxicity;Journal of Immunotoxicology;2015-09-04
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