Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease-Reference-Cited by-同舟云学术

Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease

Published:2023-10 Issue:4 Volume:15 Page:
ISSN:2352-8729
Container-title:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
language:en
Short-container-title:Alz & Dem Diag Ass & Dis Mo

Author:

Ally Madeline¹²,Sugarman Michael A.¹³,Zetterberg Henrik⁴⁵⁶⁷,Blennow Kaj⁶⁷,Ashton Nicholas J.⁷⁸⁹¹⁰,Karikari Thomas K.⁶⁷¹¹,Aparicio Hugo J.¹¹²,Frank Brandon¹¹³,Tripodis Yorghos¹¹⁴,Martin Brett¹¹⁵,Palmisano Joseph N.¹¹⁵,Steinberg Eric G.¹,Simkin Irene¹⁶,Farrer Lindsay A.¹¹²¹⁴¹⁶¹⁷,Jun Gyungah R.¹⁶,Turk Katherine W.¹¹²¹³,Budson Andrew E.¹¹²¹³,O'Connor Maureen K.¹¹⁸,Au Rhoda¹¹²¹⁷¹⁹²⁰,Goldstein Lee E.¹¹⁵²¹²²,Kowall Neil W.¹¹²¹³²³,Killiany Ronald¹²⁰²⁴,Stern Robert A.¹¹²²⁰²⁵,Stein Thor D.¹¹³²³²⁶,McKee Ann C.¹¹²¹³²³²⁶,Qiu Wei Qiao¹²⁷²⁸,Mez Jesse¹¹²,Alosco Michael L.¹¹²

Affiliation:

1. Boston University Alzheimer's Disease Research Center and CTE Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

2. Department of Psychology University of Arizona Tucson Arizona USA

3. Department of Neurology Medical University of South Carolina Charleston South Carolina USA

4. Department of Neurodegenerative Disease UCL Institute of Neurology London UK

5. UK Dementia Research Institute at UCL, UCL Institute of Neurology University College London London UK

6. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

7. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden

8. Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology, and Neuroscience King's College London London UK

9. NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation London UK

10. Centre for Age‐Related Medicine Stavanger University Hospital Stavanger Norway

11. Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA

12. Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

13. US Department of Veterans Affairs VA Boston Healthcare System Jamaica Plain Massachusetts USA

14. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA

15. Biostatistics and Epidemiology Data Analytics Center Boston University School of Public Health Boston Massachusetts USA

16. Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

17. The Framingham Heart Study Framingham Massachusetts USA

18. Department of Neuropsychology Edith Nourse Rogers Memorial Veterans Hospital Bedford Massachusetts USA

19. Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA

20. Department of Anatomy and Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

21. Department of Ophthalmology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

22. Department of Biomedical, Electrical, and Computer Engineering Boston University College of Engineering Boston Massachusetts USA

23. Department of Pathology and Laboratory Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

24. Center for Biomedical Imaging Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

25. Department of Neurosurgery Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

26. US Department of Veterans Affairs VA Bedford Healthcare System Bedford Massachusetts USA

27. Department of Psychiatry Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

28. Department of Pharmacology and Experimental Therapeutics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

Abstract

AbstractIntroductionThis study examined plasma glial fibrillary acidic protein (GFAP) as a biomarker of cognitive impairment due to Alzheimer's disease (AD) with and against plasma neurofilament light chain (NfL), and phosphorylated tau (p‐tau)181+231.MethodsPlasma samples were analyzed using Simoa platform for 567 participants spanning the AD continuum. Cognitive diagnosis, neuropsychological testing, and dementia severity were examined for cross‐sectional and longitudinal outcomes.ResultsPlasma GFAP discriminated AD dementia from normal cognition (adjusted mean difference = 0.90 standard deviation [SD]) and mild cognitive impairment (adjusted mean difference = 0.72 SD), and demonstrated superior discrimination compared to alternative plasma biomarkers. Higher GFAP was associated with worse dementia severity and worse performance on 11 of 12 neuropsychological tests. Longitudinally, GFAP predicted decline in memory, but did not predict conversion to mild cognitive impairment or dementia.DiscussionPlasma GFAP was associated with clinical outcomes related to suspected AD and could be of assistance in a plasma biomarker panel to detect in vivo AD.

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

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