Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss

Author:

Medel Vicente12ORCID,Delano Paul H.1345,Belkhiria Chama1,Leiva Alexis1,De Gatica Cristina1,Vidal Victor1,Navarro Carlos F.56,Martín Simon San15,Martínez Melissa7,Gierke Christine17,García Ximena18,Cerda Mauricio56,Vergara Rodrigo910,Delgado Carolina17,Farías Gonzalo A.178ORCID

Affiliation:

1. Departamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago Chile

2. Latin American Brain Health Institute (BrainLat) Universidad Adolfo Ibáñez Santiago Chile

3. Servicio Otorrinolaringología Hospital Clínico de la Universidad de Chile Santiago Chile

4. Advanced Center for Electrical and Electronical Engineer (AC3E) Valparaíso Chile

5. Biomedical Neuroscience Institute (BNI) Facultad de Medicina Universidad de Chile Santiago Chile

6. Integrative Biology Program Institute of Biomedical Sciences Center for Medical Informatics and Telemedicine Faculty of Medicine Universidad de Chile Santiago Chile

7. Servicio Neurología y Neurocirugía Hospital Clínico de la Universidad de Chile Santiago Chile

8. Advanced Clinical Research Center (CICA) Hospital Clínico Universidad de Chile Santiago Chile

9. Facultad de Psicología y Humanidades Universidad San Sebastián Sede Valdivia Chile

10. Centro Nacional de Inteligencia Artificial (CENIA), Chile

Abstract

AbstractINTRODUCTIONAge‐related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss.METHODSWe assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age.RESULTSWe found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR‐SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB).DISCUSSIONOur findings suggest that DPOAEs may be a non‐invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.

Publisher

Wiley

Reference42 articles.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3