Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports

Author:

Udawatta Methma12ORCID,Mateen Farrah J.2ORCID

Affiliation:

1. Department of Neurology Brigham and Women's Hospital Boston Massachusetts USA

2. Department of Neurology Massachusetts General Hospital Boston Massachusetts USA

Abstract

AbstractNicolau syndrome is a rare, iatrogenic skin reaction after parental drug administration, characterized by severe pain at an injection site, followed by hemorrhage, ulceration, and often necrosis. We present a case of a patient on glatiramer acetate for many years (initially Copaxone then Glatopa) who developed Nicolau syndrome, the second reported case after generic glatiramer acetate. All reported cases of Nicolau syndrome after glatiramer acetate are reviewed. The case highlights the importance of prompt recognition of this skin reaction by neurologists and raises awareness of the risks of skin reactions even in low‐risk injectable DMTs.

Publisher

Wiley

Reference34 articles.

1. Nicolau Syndrome (Embolia Cutis Medicamentosa): A Rare and Poorly Recognized Iatrogenic Cause of Cutaneous Thrombotic Vasculopathy

2. Lokales embolisches Bismugenol Exanthem, Sitzungs‐bericht der Schlesischen Dermatologischen Gesellschaft vom [in German];Freudenthal W;Geschlechtskr,1924

3. Dermite livédoidé et gangréneuse de la fesse consecutive aux injections intramusculaire de la syphilis [in French];Nicolau P;Ann Venereol Mal Venereol,1925

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