In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry-Reference-Cited by-同舟云学术

In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry

Published:2018-02-15 Issue:6 Volume:32 Page:480-488
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun Mass Spectrom

Author:

Sun Wenchao¹^ORCID,Nguyen Khoa Dinh²,Fitch William L.¹,Banister Samuel D.³,Tang Hongxiang¹,Zhang Xiaolan¹,Yu Lewis²,Engleman Edgar G.²,Rajadas Jayakumar¹⁴

Affiliation:

1. Biomaterials and Advance Drug Delivery Lab, School of Medicine; Stanford University; Stanford CA 94304 USA

2. Department of Pathology, School of Medicine; Stanford University; Stanford CA 94304 USA

3. Medicinal Chemistry Knowledge Center, ChEM-H; Stanford University; Stanford CA 94304 USA

4. Department of Bioengineering and Therapeutic Sciences, School of Pharmacy; University of California; San Francisco CA USA

Funder

Larry L. Hillblom Foundation

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference22 articles.

1. Benzimidazole drugs and modulation of biotransformation enzymes;Velik;Res Vet Sci,2004

2. The therapeutic journey of benzimidazoles: A review;Bansal;Bioorg Med Chem,2012

3. Novel small-molecule PGC-1 alpha transcriptional regulator with beneficial effects on diabetic db/db mice;Zhang;Diabetes,2013

4. PGC-1alpha (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) overexpression in coronary artery disease recruits NO and hydrogen peroxide during flow-mediated dilation and protects against increased intraluminal pressure;Kadlec;Hypertension,2017

5. ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy;Li;Exp Cell Res,2016

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of glycolytic reprogramming suppresses innate immune-mediated inflammation in experimental amyotrophic lateral sclerosis;Inflammation Research;2024-08-21

2. ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis;Journal of Hazardous Materials;2024-06

3. PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration;Advanced Science;2024-03-30

4. 5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation;Frontiers in Pharmacology;2022-03-03

5. Pharmacologic induction of PGC ‐1α stimulates fetal haemoglobin gene expression;British Journal of Haematology;2022-02-04