Effect of resveratrol and curcumin and the potential synergism on hypertension: A mini‐review of human and animal model studies-Reference-Cited by-同舟云学术

Effect of resveratrol and curcumin and the potential synergism on hypertension: A mini‐review of human and animal model studies

Published:2023-10-02 Issue:1 Volume:38 Page:42-58
ISSN:0951-418X
Container-title:Phytotherapy Research
language:en
Short-container-title:Phytotherapy Research

Author:

Ghaeini Hesarooeyeh Zahra¹,Basham Ayoub¹,Sheybani‐Arani MohammadHosein¹,Abbaszadeh Mahshid²,Salimi Asl Ali¹,Moghbeli Meysam³,Saburi Ehsan³⁴^ORCID

Affiliation:

1. Student Research Committee, Faculty of Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran

2. Student Research Committee, School of Dentistry Hormozgan University of Medical Sciences Bandar Abbas Iran

3. Medical Genetics Research Center Mashhad University of Medical Sciences Mashhad Iran

4. Department of Medical Genetics and Molecular Medicine, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran

Abstract

AbstractResveratrol (RES) and curcumin (CUR) are two of the most extensively studied bioactive compounds in cardiovascular research from the past until today. These compounds have effectively lowered blood pressure by downregulating the renin‐angiotensin system, exerting antioxidant effects, and exhibiting antiproliferative activities on blood vessels. This study aims to summarize the results of human and animal studies investigating the effects of CUR, RES, and their combination on hypertension and the molecular mechanisms involved. The published trials' results are controversial regarding blood pressure reduction with different doses of RES and CUR, highlighting the need to address this issue.

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.8023

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