Utilization trend of prebiopsy multiparametric magnetic resonance imaging and its impact on prostate cancer detection: Real‐world insights from a high‐volume center in southwest China

Abstract

AbstractBackgroundData on the utilization and effects of prebiopsy prostate multiparametric magnetic resonance imaging (mpMRI) to support its routine use in real‐world setting are still scarce.ObjectiveTo evaluate the change of clinical practice of prebiopsy mpMRI over time, and assess its diagnostic accuracy.Design, Setting, and ParticipantsWe retrospectively analyzed data from 6168 patients who underwent primary prostate biopsy (PBx) between January 2011 and December 2021 and had prostate‐specific antigen (PSA) values ranging from 3 to 100 ng/mL.InterventionPrebiopsy MRI at the time of PBx.Outcome Measurements and Statistical AnalysisWe performed general linear regression and to elucidate trends in the annual use of prebiopsy mpMRI and conducted multivariable logistic regression to evaluate the potential benefits of incorporating prebiopsy mpMRI for prostate cancer (PCa) detection.Results and LimitationsThe utilization of prebiopsy mpMRI significantly increased from 9.2% in 2011 to 75.0% in 2021 (p < 0.001). In addition, prebiopsy mpMRI significantly reduced negative PBx by 8.6% while improving the detection of clinically significant PCa (csPCa) by 7.0%. Regression analysis showed that the utilization of prebiopsy mpMRI was significantly associated with a 48% (95% confidence interval [CI]: 1.19–1.84) and 36% (95% CI: 1.12–1.66) increased PCa detection rate in the PSA 3–10 ng/mL and 10–20 ng/mL groups, respectively; and a 34% increased csPCa detection rate in the PSA 10–20 ng/mL group (95% CI: 1.09–1.64). The retrospective design and the single center cohort constituted the limitations of this study.ConclusionsOur study demonstrated a notable rise in the utilization of prebiopsy mpMRI in the past decade. The adoption of this imaging technique was significantly associated with an increased probability of detecting prostate cancer.Patient SummaryFrom 2011 to 2021, we demonstrated a steady increase in the utilization of prebiopsy mpMRI among biopsy‐naïve men. We also confirmed the positive impact of prebiopsy mpMRI utilization on the detection of prostate cancer.