The association between several serum micronutrients and benign prostatic hyperplasia: Results from NHANES 2003−2006

Abstract

AbstractBackgroundBenign prostatic hyperplasia (BPH) is a common condition that affects the quality of life of older men. Specific micronutrients, including retinol, retinyl esters, carotenoids, vitamin E, and vitamin C, have antioxidant and anti‐inflammatory properties. However, the correlation between serum concentrations of these micronutrients and BPH is unclear.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES), which included 2067 representative US men. BPH was assessed using the self‐reported questionnaire. This association was explored by adjusting for confounders using multivariate logistic regression.ResultsAfter fully adjusting for confounders, for every 0.01 μmol/L increase in serum retinyl esters, the risk of BPH increased by 2% (OR = 1.02; 95% CI: 1.01−1.03; p = 0.006). Based on the Bonferroni‐corrected p‐value, we found this correlation to be significant. One μmol/L increase in total carotenoids was associated with a 22% increase in BPH risk (OR = 1.22; 95% CI: 1.03−1.46; p = 0.025). By analyzing the correlation between different types of carotenoids and BPH, we also found that β‐carotenoids (OR = 1.43; 95% CI: 1.03−1.99; p = 0.036) was also positively correlated with BPH. The subgroup analysis revealed a positive correlation between serum vitamin E (OR = 1.02; 95% CI: 1.00−1.04; p = 0.018) and BPH in men under 60 years of age. Serum retinyl ester (OR = 1.02; 95% CI: 1.01−1.04; p = 0.008) and carotenoid (OR = 1.52; 95% CI: 1.22−1.87; p < 0.001) concentrations were positively correlated with BPH in men over 60 years of age.ConclusionOur study suggests that excessive serum retinyl esters, total carotenoids, and especially β‐carotenoids are potential risk factors for BPH, and this association should be further investigated.