Prognostic value of preoperative combined neutrophil, monocyte, and lymphocyte scores in patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A retrospective study

Author:

Ni Jinliang12,Yao Xiaoxiang3,Song Wei24,Zhang Heng5,Zhang Houliang6,Wang Yidi7,Zhang Yifan2,Wang Guangchun2,Wang Keyi12,Mao Weipu6,Peng Bo24

Affiliation:

1. Department of Urology, Shanghai Putuo District People's Hospital, School of Medicine Tongji University Shanghai China

2. Department of Urology, Shanghai Tenth People's Hospital, School of Medicine Tongji University Shanghai Shanghai China

3. Department of Oncology, Putuo People's Hospital, School of Medicine Tongji University Shanghai China

4. Shanghai Clinical College Anhui Medical University Shanghai China

5. Department of Urology Guiqian International General Hospital Guizhou China

6. Department of Urology Affiliated Zhongda Hospital of Southeast University Nanjing China

7. Department of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou China

Abstract

AbstractBackgroundIn a multi‐institutional clinical study, we assessed the prognostic significance of a novel indicator preoperative peripheral blood immune (PBIS) scores that combined ratios of preoperative lymphocyte, monocyte, and neutrophil of renal cell carcinoma (RCC) patients undergoing laparoscopic nephrectomy.MethodsBetween January 2014 and December 2019, 438 patients with RCC were retrospectively analyzed in three centers. We used X‐tile software to obtain the optimum cut‐off values for neutrophils, monocytes, and lymphocytes to classify the patients. To assess the relationship between PBIS score and overall survival (OS), and cancer‐specific survival (CSS) in patients with RCC by Kaplan–Meier survival curves and Cox regression analyses. In addition, predictive OS and CSS nomograms were constructed. The discriminative ability of nomogram and predictive performance accuracy were verified with consistency index (C‐index), calibration curves, receiver operating curve (ROC) curves, decision curve analysis (DCA) curves, and time‐dependent ROC curves.ResultsThe optimum cutoff values for monocytes, lymphocytes, and neutrophils were 0.46, 1.01, and 4.50, respectively. We divided patients into four subgroups according to PBIS scores, which were significantly associated with M‐stage (p = 0.008), T‐stage (p < 0.001), N‐stage (p = 0.006), and AJCC stage (p < 0.001). Multivariate Cox regression analysis revealed that RCC patients with lower PBIS scores showed a worse postoperative prognosis and served as an independent predictor of OS (p = 0.002) and CSS (p < 0.001). Ultimately, the nomograms based on PBIS scores demonstrated excellent predictive performance for OS (C‐index: 0.770) and CSS (C‐index: 0.828) through the analysis of calibration curves, ROC curves, DCA curves, and time‐dependent ROC curves.ConclusionPBIS score served as novel and effective predictor to accurately predict OS and CSS in patients with RCC receiving laparoscopic nephrectomy.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Wiley

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