Affiliation:
1. School of medicine Isfahan university of medical sciences Isfahan Iran
2. Infectious Diseases and Tropical Medicine Research Center Isfahan University of Medical Sciences Isfahan Iran
3. Department of Neurology, School of Medicine Isfahan University of Medical Sciences Isfahan Iran
Abstract
Key Clinical MessageEpstein–Barr virus (EBV) is a commonly asymptomatic widespread human herpes virus affecting over 90% of the population. It mostly originates complications like simple sore throat and infectious mononucleosis but severe manifestations are rare. Herein we report a 30‐year‐old immunocompetent man who presented with fever, sore throat, general weakness, and drowsiness. The diagnosis was formulated based on the positive RT‐PCR test for EBV DNA and serological detection of IgM antibody against viral capsid antigen. The patient developed severe meningoencephalitis, myocarditis, and bowel perforation and passed away after 72 days of hospitalization.