A Structural Rationale for N ‐Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand‐Gated Ion Channels
Author:
Affiliation:
1. Division of Biological Chemistry and Drug Discovery School of Life SciencesUniversity of Dundee Dow St Dundee DD1 5EH UK
2. Division of Systems MedicineSchool of MedicineNinewells HospitalUniversity of Dundee Dundee DD1 9SY UK
Funder
Wellcome Trust
Publisher
Wiley
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201900680
Reference41 articles.
1. GABA, Bicuculline and Central Inhibition
2. Bicuculline Methochloride as a GABA Antagonist
3. Advantages of an antagonist: bicuculline and other GABA antagonists
4. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat
5. Evaluation of Bicuculline as a GABA Antagonist
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