Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin

Abstract

Herein, a detailed account of the efforts leading to the recently published synthesis of the Ganoderma meroterpenoid ganoapplanin, a natural product identified as an inhibitor of T‐type voltage‐gated calcium channels, is provided. Ganoapplanin, which was isolated as a racemate from the fungus Ganoderma applanatum in 2016, features a complex structure, including a characteristic spiro bisacetal structure, a highly functionalized tetra‐ortho‐substituted biaryl motif, and a propellane‐like dioxatricyclo[4.3.3.0]dodecane scaffold. While the southern terpenoid fragment is available via a diastereoselective titanium‐mediated iodolactonization, considerable efforts are required to fuse this fragment with various aromatic fragments. The breakthrough was achieved by a highly efficient two‐component coupling strategy that simultaneously fuses the fragments and establishes the crucial biaryl bond. This transformation involves an intramolecular 6‐exo‐trig radical addition of a quinone monoacetal, followed by an intermolecular aldol addition. Finally, strategic late‐stage oxidations enabled the formation of the characteristic spiro bisacetal motif and the completion of the synthesis of ganoapplanin.