Affiliation:
1. Department of Studies and Research in Chemistry Mangalore University Mangalagangothri 574199 India
2. Department of Chemistry Sri Dharmasthala Manjunatheshwara College (Autonomous) Ujire 574240 India
3. Department of Biotechnology and Bioinformatics JSS Academy of Higher Education and Research Mysuru 570015 India
Abstract
AbstractDiabetic complications poses major threat to mankind which found to be dangerously fatal all over the world. It is thought vital to find new class of molecules to combat diabetic problems. Thus, in continuation of our efforts in identifying new class of α‐glucosidase and α‐amylase inhibitors, a novel series of hybrid molecules comprising of imidazo[1,2‐a]pyridine and pyrazoles, i. e. (3‐(Substituted phenyl)‐1H‐pyrazol‐4‐yl)methylene)‐2,7‐dimethyl‐1H‐imidazo[1,2‐a]pyridine‐3‐carbohydrazide derivatives (8 a–m) were designed through a acyl hydrazone bridge. The compound (Z)‐N′‐({3‐[4‐(2‐Fluorobenzyloxy)phenyl]‐1H‐pyrazol‐4‐yl}methylene)‐2,7‐dimethyl‐imidazo[1,2‐a]pyridine‐3‐carbohydrazide (8 m) emerged as potent inhibitor of α‐glucosidase and α‐amylase enzyme with IC50 5.00±0.10 μg/mL and 15±0.35 μg/mL respectively. The enzyme kinetics studies revealed reversible non‐competitive mode of inhibition of 8 m against both enzymes. In addition, these compounds were subjected to detailed in‐silico studies to understand their interaction with respective target proteins.