Affiliation:
1. Department of Chemistry School of Advanced Science Vellore Institute of Technology Katpadi 632014 Vellore Tamil Nadu India
2. Department of Chemistry Central Tribal University of Andhra Pradesh Kondakarakam Village, Cantonment area 535003 Vizianagaram Andhra Pradesh India
Abstract
AbstractAn efficient TMSOTf‐promoted multicomponent reaction has been developed for the one‐pot synthesis of quinazolin‐4 (3H)‐ones. Using the TMSOTf as a Lewis acid promoter and DMSO as a carbon source, the reaction of isatoic anhydride, primary amines yielded a variety of quinazolines‐4 (3H)‐ones. Additionally, TMSOTf promoted the reaction of 2‐amino‐N‐substituted benzamide with DMSO yielding the same scaffolds in high yields. However, the use of DMSO‐d6 as a solvent in the reaction enabled the incorporation of the −CD moiety in quinazolines‐4 (3H)‐one skeleton. This proves that DMSO plays a twin role as a C1 source and solvent. Various functional groups containing a wide range of quinazolin‐4 (3H)‐ones and other heterocycles were developed employing this methodology. Also, the synthetic methodology has been extended for the synthesis of 3‐(2‐carboxyphenyl)‐4‐(3H)‐quinazolinone, as an anti‐endotoxic drug.
Funder
Vellore Institute of Technology, Chennai