A New family of Sulfamidophosphonates Derivatives: Microwave‐Accelerated Multicomponent Synthesis, Characterization and X‐Ray Crystallographic Study**

Author:

Ghodbane Racha1,K'Tir Hacène12,Bouacida Sofiane34,Ibrahim‐Ouali Malika5,Aouf Zineb1,Aouf Nour‐Eddine1

Affiliation:

1. Chemistry Department Laboratory of Applied Organic Chemistry Bioorganic Chemistry Group Badji Mokhtar-Annaba University Box 12 23000 Annaba Algeria

2. Medical Sciences faculty Badji-Mokhtar-Annaba University Box 12 Annaba 230 0 0 Algeria

3. Department of Materials Science Larbi Ben Mhidi University Oum El Bouaghi 04000 Algeria

4. Chemistry Department University of Constantine 1 Constantine 25000 Algeria

5. Chemistry Department Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, F- 13397 Marseille France

Abstract

AbstractIn this present study, we describe a simple, effective and greener one‐pot microwave‐assisted synthesis of novel α‐sulfamidophosphonates 4(al), and 5(a, b) that were rationally designed and synthesized following the principle of the superposition of bioactives substructures. This reaction was accomplished by the condensation of various aromatic aldehydes, sulfamide and diethyl phosphite via the Kabachnik‐Fields reaction using ethanol as solvent under catalyst‐free conditions. The corresponding products were obtained with good yields, in short reactions time and no side product was observed. All the newly synthesized compounds were systematically characterized by IR, 1H NMR, 13C NMR and 31P NMR analysis and the structures of the compounds 4 b and 4 c were further analyzed by single crystal X‐ray diffraction.

Publisher

Wiley

Subject

General Chemistry

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