Synthesis, Characterization, Molecular Docking and in vitro Anticancer Screening of Some Novel Thiophene Derivatives

Author:

Patel Ashish K.1ORCID,Patel Purvesh R.1ORCID,Patel Bhavin H.1ORCID,Shah Ujashkumar A2ORCID,Soni Jigar Y.3ORCID,Valand Nikunj4ORCID,Teli Divya M.5ORCID,Soni Hemal6,Patel Manish B7ORCID

Affiliation:

1. Sankalchand Patel University Faculty of Science & Humanities Visnagar Gujarat 384315 India

2. Nootan Pharmacy College Sankalchand Patel University Visnagar Gujarat 384315 India

3. Department of Chemistry Faculty of Basic and Applied Sciences Madhav University Abu Road Sirohi Rajasthan 307026 India

4. Department of Chemistry Institute of Science Humanities and Liberal Studies Indus University Ahmedabad Gujarat 382115 India

5. Department of Pharmaceutical Chemistry L. M. College of Pharmacy Ahmedabad Gujarat 380009 India

6. HOD, Chemistry o2h discovery pvt ltd Ahmedabad Gujarat 382213 India

7. Department of Chemistry Shri M. R. Arts & Science College Rajpipla Veer Narmad South Gujarat University Gujarat 393145 India

Abstract

AbstractOne of the diseases in the 21st century is still cancer and there is significant research being done all over the world to find a medicine that is more effective and has fewer adverse effects. More than 19 million new cases of cancer have been reported by global statistics and an estimated 10 million people have died from it in 2020. We continue to work on the development of new pharmacological entities because we are motivated in the research area. We have created novel thiophene derivatives and have screened them against the U87‐MG cell line to see whether they have any anticancer properties. It was observed that the AP‐C12 extract showed the highest inhibition in the U87‐MG cell line (EC50: 9.1 μM) which was a very good comparison to Temozolomide (EC50: 61.2 μM). Similarly, AP‐C7 exhibited considerable potency against the U87‐MG cell line with EC50 values of 12.3 μM.

Publisher

Wiley

Subject

General Chemistry

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