Analysis of Mixed Micellization of Promethazine Hydrochloride and 1‐Hexadecyl‐3‐Methylimidazolium Chloride Using Different Techniques: Influence of Additives

Abstract

AbstractUsing tensiometric technique in various solvents, the interaction of phenothiazine drug promethazine hydrochloride (PMH) and ionic liquid 1‐hexadecyl‐3‐methylimidazolium chloride (HICL‐16) mixture at 298.15 K was examined. Here, both the employed components (PMH and HICL‐16) are cationic in nature. Since mixed amphiphile systems are widely applied and economically viable, considerable research has been devoted to investigating their physicochemical properties. Interaction amongst PMH and HICL‐16 in aqueous has also been explored using UV–visible method. Tensiometric method was used to assess the critical micelle concentration (cmc) of pure (PMH and HICL‐16) as well as mixtures, and the results (deviation from their ideal cmc (cmcid) value) revealed that mixtures cmc showed non‐ideal behavior. Compared to an aqueous solution, the cmc of system (pure/mixture) decreased in the occurrence of employed concentration of fructose and glucose whereas it increased in urea solvent, and glucose is more efficient in diminishing cmc than fructose. Evaluated interaction parameter (βm) value of mixed micelles showed that PMH and HICL‐16 have an attractive interaction or synergy. Attained negative Gibbs free energy () was accomplished owing to the spontaneity nature of micelles formation. A UV–visible study exposed an interaction between PMH and HICL‐16, as PMH absorbance increased with HICL‐16 concentration.