Affiliation:
1. Department of Chemistry University of Utah 315 South 1400 East Salt Lake City UT-84112 USA
2. Radiology Department University of Pennsylvania 3400 Spruce St, 1 Silverstein Philadelphia PA-19104 USA
Abstract
AbstractWe prepared novel mesoporous organosilica nanoparticles with internal metal‐chelating diethylenetriametetraacetic acid groups (DTTA‐MSNPs) by co‐condensation and decorated them with fluorescent moieties. We studied the binding of transition metal ions such as copper(II), cobalt (II) and gadolinium (III) by DTTA‐MSNPs, and found high uptake of these metals. In particular, DTTA‐MSNPs uptake ~1.1×105 Gd3+ per particle and possess a high r1 relaxivity of 15.27 mM−1 s−1. Thus, DTTA‐MSNPs may find applications in metal sequestration and in MR imaging and neutron capture therapy.