Gamma‐band harmonic responses for beta‐band auditory steady‐state response are intact in patients with early stage schizophrenia

Author:

Tada Mariko123ORCID,Kirihara Kenji14,Nagai Tatsuya1,Koike Shinsuke1256,Araki Tsuyoshi17,Kasai Kiyoto12

Affiliation:

1. Department of Neuropsychiatry The University of Tokyo Hospital Tokyo Japan

2. International Research Center for Neurointelligence (WPI‐IRCN), UTIAS The University of Tokyo Tokyo Japan

3. Office for Mental Health Support Center for Research on Counseling and Support Services The University of Tokyo Tokyo Japan

4. Disability Services Office The University of Tokyo Tokyo Japan

5. The University of Tokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM) Tokyo Japan

6. Center for Evolutionary Cognitive Sciences Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan

7. Department of Psychiatry Teikyo University Hospital Kanagawa Japan

Abstract

AbstractGamma oscillations, thought to arise from the activity of ɣ‐aminobutyric acid (GABA)ergic interneurons, have potential as a biomarker for schizophrenia. Gamma‐band auditory steady‐state responses (ASSRs) are notably reduced in both chronic and early‐stage schizophrenia patients. Furthermore, alterations in gamma‐band ASSRs have been demonstrated in animal models through translational research. However, the 40‐Hz harmonic responses of the 20‐Hz ASSR are not as well‐characterized, despite the possibility that these harmonic oscillatory responses may reflect resonant activity in neural circuits. In this study, we investigated the 40‐Hz harmonic response to the 20‐Hz ASSR in the early stages of schizophrenia. The study recruited 49 participants, including 15 individuals at ultra‐high‐risk (UHR) for psychosis, 13 patients with first‐episode schizophrenia (FES), and 21 healthy controls (HCs). The 40‐Hz harmonic responses of the 20‐Hz ASSR were evident in all groups. Interestingly, while previous report observed reduced 40‐Hz ASSRs, the 40‐Hz harmonic responses of the 20‐Hz ASSR were not reduced in the UHR or FES groups. These findings suggest that the gamma‐band ASSR and its harmonic responses may represent distinct aspects of pathophysiology in the early stages of schizophrenia.

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology,Clinical Psychology

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