First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

Author:

Brussee Janneke M.1ORCID,Yu Huixin1,Krekels Elke H. J.1ORCID,de Roos Berend1,Brill Margreke J. E.2,van den Anker Johannes N.345,Rostami-Hodjegan Amin67,de Wildt Saskia N.38,Knibbe Catherijne A. J.19

Affiliation:

1. Division of Systems Biomedicine and Pharmacology; Leiden Academic Centre for Drug Research (LACDR), Leiden University; Leiden The Netherlands

2. Department of Pharmaceutical Biosciences; Uppsala University; Uppsala Sweden

3. Intensive Care and Department of Pediatric Surgery; Erasmus MC - Sophia Children's Hospital; Rotterdam The Netherlands

4. Division of Paediatric Pharmacology and Pharmacometrics; University of Basel Children's Hospital; Basel Switzerland

5. Division of Clinical Pharmacology; Children's National Health System; Washington DC

6. Centre for Applied Pharmacokinetic Research, University of Manchester; Manchester UK

7. Simcyp Limited (A Certara Company); Sheffield UK

8. Department of Pharmacology and Toxicology; Radboud University Medical Centre; Nijmegen The Netherlands

9. Department of Clinical Pharmacy; St. Antonius Hospital; Nieuwegein The Netherlands

Funder

NWO

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

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