Affiliation:
1. Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China
Abstract
AbstractGeminal‐difluoroalkanes featuring intriguing steric and electronic properties are of great significance in medicinal chemistry, and great progresses have been achieved for their synthesis. In recent years, iodine(III) reagent‐mediated migratory gem‐difluorination of alkenes has proved to be an efficient and powerful strategy to access to diverse gem‐difluoroalkanes, especially those bearing a readily transformable functionality (TF), which are important for rapid assembly of complex gem‐difluorinated molecules in a modular and diverse manner. In this review, we systematically summarize the recent development of iodine(III)‐mediated migratory gem‐difluorination reactions for the synthesis of gem‐difluoroalkanes bearing a synthetically versatile TF at the β position. The reaction mechanism and the utilities of the products are also discussed. This review is presented and grouped basically according to the types of transformable functionalities within the products.
Funder
National Natural Science Foundation of China
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry