Quantitative Systems Pharmacology: A Case for Disease Models

Author:

Musante CJ1,Ramanujan S2,Schmidt BJ3,Ghobrial OG4,Lu J5,Heatherington AC1

Affiliation:

1. Pfizer Inc; Cambridge Massachusetts USA

2. Genentech; South San Francisco California USA

3. Bristol-Myers Squibb; Princeton New Jersey USA

4. No institutional affiliation at the time of this research

5. AstraZeneca; Cambridge UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference10 articles.

1. Good practices in model-informed drug discovery and development (MID3): practice, application and documentation;EFPIA MID3 Workgroup;CPT Pharmacometrics Syst. Pharmacol.,2016

2. NIH QSP Workshop Group Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms -- An NIH White Paper by the QSP Workshop Group 2011 Ward , R.

3. Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development;Graaf;Pharm. Res.,2011

4. Clinical development success rates for investigational drugs;Hay;Nat. Biotechnol.,2014

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