Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival
Author:
Affiliation:
1. a Department of Reproductive Medicine, University of California, San Diego, La Jolla, California, USA
2. b Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA
Abstract
Funder
UCSD Department of Reproductive Medicine and the California Institute of Regenerative Medicine
Millipore, Inc.
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Developmental Biology,Molecular Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/stem.2550
Reference48 articles.
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3. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture;Laurent;Cell Stem Cell,2011
4. Temporal analysis of genome alterations induced by single-cell passaging in human embryonic stem cells;Bai;Stem Cells Dev,2015
5. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions;Garitaonandia;PloS One,2015
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