Affiliation:
1. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Department of Orthopedics Tongji Hospital affiliated to Tongji University School of Life Science and Technology School of Medicine Tongji University Shanghai 200065 China
2. Department of Endocrinology and Metabolism Gongli Hospital of Shanghai Pudong New Area Shanghai 200135 China
3. Frontier Science Center for Stem Cell Research Tongji University Shanghai 200065 China
Abstract
AbstractBone tissue defects present a major challenge in orthopedic surgery. Bone tissue engineering using multiple versatile bioactive materials is a potential strategy for bone‐defect repair and regeneration. Due to their unique physicochemical and mechanical properties, biofunctional materials can enhance cellular adhesion, proliferation, and osteogenic differentiation, thereby supporting and stimulating the formation of new bone tissue. 3D bioprinting and physical stimuli‐responsive strategies have been employed in various studies on bone regeneration for the fabrication of desired multifunctional biomaterials with integrated bone tissue repair and regeneration properties. In this review, biomaterials applied to bone tissue engineering, emerging 3D bioprinting techniques, and physical stimuli‐responsive strategies for the rational manufacturing of novel biomaterials with bone therapeutic and regenerative functions are summarized. Furthermore, the impact of biomaterials on the osteogenic differentiation of stem cells and the potential pathways associated with biomaterial‐induced osteogenesis are discussed.
Funder
National Science Fund for Distinguished Young Scholars
National Key Research and Development Program of China
National Natural Science Foundation of China
Cited by
4 articles.
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