Signal Transduction in Artificial Cells

Author:

Yu Xiaolei12,Mukwaya Vincent12,Mann Stephen123,Dou Hongjing12ORCID

Affiliation:

1. State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

2. Zhangjiang Institute for Advanced Study (ZIAS) Shanghai Jiao Tong University Shanghai 201203 China

3. Max Planck Bristol Centre for Minimal Biology and Centre for Protolife Research School of Chemistry University of Bristol Bristol BS8 1TS UK

Abstract

AbstractIn recent years, significant progress has been made in the emerging field of constructing biomimetic soft compartments with life‐like behaviors. Given that biological activities occur under a flux of energy and matter exchange, the implementation of rudimentary signaling pathways in artificial cells (protocells) is a prerequisite for the development of adaptive sense‐response phenotypes in cytomimetic models. Herein, recent approaches to the integration of signal transduction modules in model protocells prepared by bottom‐up construction are discussed. The approaches are classified into two categories involving invasive biochemical signals or non‐invasive physical stimuli. In the former mechanism, transducers with intrinsic recognition capability respond with high specificity, while in the latter, artificial cells respond through intra‐protocellular energy transduction. Although major challenges remain in the pursuit of a sophisticated artificial signaling network for the orchestration of higher‐order cytomimetic models, significant advances have been made in establishing rudimentary protocell communication networks, providing novel organizational models for the development of life‐like microsystems and new avenues in protoliving technologies.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Materials Science,General Chemistry

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