Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative-Reference-Cited by-同舟云学术

Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative

Published:2023-12-17 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Sanchez Erlan¹,Wilkinson Tim¹,Coughlan Gillian²,Mirza Saira¹³,Baril Andrée‐Ann⁴,Ramirez Joel⁵,Binns Malcolm A.⁶⁷,Black Sandra E.³⁵,Borrie Michael⁸⁹,Dilliott Allison A.¹⁰,Dixon Roger A.¹¹,Dowlatshahi Dar¹²¹³,Farhan Sali¹⁰,Finger Elizabeth⁸⁹,Fischer Corinne E.¹⁴,Frank Andrew¹⁵,Freedman Morris³⁶¹⁶,Goncalves Rafaella A.¹⁷,Grimes David A.¹²¹³¹⁸,Hassan Ayman¹⁹,Hegele Robert A.⁹²⁰,Kumar Sanjeev²¹²²,Lang Anthony E.³²³,Marras Connie²³,McLaughlin Paula M.²⁴²⁵,Orange Joseph B.²⁶²⁷,Pasternak Stephen H.²⁸²⁹,Pollock Bruce G.²¹²²³⁰,Rajji Tarek K.²¹²²,Roberts Angela C.²⁶²⁷,Robinson John F.⁹²⁰,Rogaeva Ekaterina³¹,Sahlas Demetrios J.³²,Saposnik Gustavo³³³,Strong Michael J.⁹³⁴,Swartz Richard H.³³⁵,Tang‐Wai David F.³³⁶,Tartaglia Maria Carmela³¹³⁶,Troyer Angela K.³⁷³⁸,Kvartsberg Hlin³⁹⁴⁰,Zetterberg Henrik³⁹⁴⁰⁴¹⁴²⁴³,Munoz Douglas P.¹⁷,Masellis Mario¹³,

Affiliation:

1. L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Ontario Canada

2. Department of Neurology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA

3. Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada

4. Douglas Mental Health University Institute McGill University Montreal Quebec Canada

5. Dr. Sandra Black Centre for Brain Resilience & Recovery Hurvitz Brain Sciences Research Program Sunnybrook Research Institute Toronto Ontario Canada

6. Rotman Research Institute Baycrest Health Sciences Toronto Ontario Canada

7. Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada

8. Lawson Health Research Institute London Ontario Canada

9. Schulich School of Medicine & Dentistry Western University London Ontario Canada

10. Department of Neurology and Neurosurgery Montreal Neurological Institute‐Hospital McGill University Montreal Quebec Canada

11. Department of Psychology Neuroscience and Mental Health Institute University of Alberta Edmonton Alberta Canada

12. Department of Medicine University of Ottawa Ottawa Ontario Canada

13. Ottawa Hospital Research Institute Ottawa Ontario Canada

14. Keenan Research Centre for Biomedical Research Li Ka Shing Knowledge Institute St. Michael's Hospital Toronto Ontario Canada

15. Bruyere Research Institute University of Ottawa Ottawa Ontario Canada

16. Department of Medicine Mt. Sinai Hospital Toronto Ontario Canada

17. Centre for Neuroscience Studies Queen's University Kingston Ontario Canada

18. Brain and Mind Research Institute Ottawa Ontario Canada

19. Thunder Bay Regional Research Institute Northern Ontario School of Medicine Thunder Bay Ontario Canada

20. Robarts Research Institute Western University London Ontario Canada

21. Centre for Addiction and Mental Health Toronto Ontario Canada

22. Department of Psychiatry University of Toronto Toronto Ontario Canada

23. Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre Toronto Western Hospital Toronto Ontario Canada

24. Nova Scotia Health Halifax Nova Scotia Canada

25. Department of Medicine Dalhousie University Halifax Nova Scotia Canada

26. School of Communication Sciences and Disorders Western University London Ontario Canada

27. Canadian Centre for Activity and Aging Western University London Ontario Canada

28. Department of Clinical Neurological Sciences Robarts Research Institute Western University London Ontario Canada

29. Parkwood Institute, St. Joseph's Health Care Centre Western University London Ontario Canada

30. Department of Pharmacology and Toxicology University of Toronto Toronto Ontario Canada

31. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada

32. McMaster University Hamilton Ontario Canada

33. Stroke Outcomes and Decision Neuroscience Unit, Li Ka Shing Knowledge Institute St. Michael's Hospital Toronto Ontario Canada

34. Canadian Institutes for Health Research Ottawa Ontario Canada

35. Sunnybrook Research Institute Sunnybrook Health Sciences Centre Toronto Ontario Canada

36. Krembil Brain Institute Memory Clinic University Health Network Toronto Ontario Canada

37. Department of Psychology University of Toronto Toronto Ontario Canada

38. Neuropsychology and Cognitive Health Baycrest Health Sciences Toronto Ontario Canada

39. Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

40. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

41. Dementia Research Institute Department of Neurodegenerative Disease UCL Institute of Neurology Queen Square London UK

42. Hong Kong Center for Neurodegenerative Diseases Hong Kong China

43. Wisconsin Alzheimer's Disease Research Center University of Wisconsin Madison Wisconsin USA

Abstract

AbstractINTRODUCTIONWe investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.METHODSGlial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p‐tau)181 and amyloid beta (Aβ)42/40 were measured using ultra‐sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD).RESULTSGFAP, NfL, and/or p‐tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p‐tau181 were highly predictive across diseases, p‐tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ42/40.DISCUSSIONGFAP, NfL, and p‐tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.

Funder

Ontario Brain Institute

Alberta Innovates

Canadian Institutes of Health Research

Vetenskapsrådet

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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