Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets

Author:

Bourne Christina R.1,Wakeham Nancy1,Bunce Richard A.2,Nammalwar Baskar2,Darrell Berlin K.2,Barrow William W.1

Affiliation:

1. Department of Veterinary Pathobiology; Oklahoma State University; 250 McElroy Hall; Stillwater; OK; 74078; USA

2. Department of Chemistry; Oklahoma State University; 107 Physical Sciences 1; Stillwater; OK; 74078; USA

Publisher

Wiley

Subject

Molecular Biology,Structural Biology

Reference60 articles.

1. RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine;Bailey;Antimicrob. Agents Chemother.,2008

2. Academic screening goes high-throughput;Baker;Nat. Methods,2010

3. Barrow EW Bourne PC Clinkenbeard KD Morton RJ Wyckoff JH Clinkenbeard PA Duncan RA Gates C Valderas MW Barrow WW 2007a MIC and FIC Evaluations of Select Agents Using High-throughput Screening, Abstract 072 (D)

4. In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis;Barrow;Antimicrob. Agents Chemother.,2007b

5. Biolog (Application Notes) Identifying Antimicrobials and Their Mechanism of Action Using Phenotype Microarrays

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