A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

Author:

Bowman Brittany M1ORCID,Montgomery Stephanie A12,Schrank Travis P13,Simon Jeremy M145ORCID,Ptacek Travis S15,Tamir Tigist Y6ORCID,Mulvaney Kathleen M7,Weir Seth J1ORCID,Nguyen Tuong T8,Murphy Ryan M6ORCID,Makowski Liza910ORCID,Hayes D Neil9ORCID,Chen Xiaoxin L1112ORCID,Randell Scott H1713ORCID,Weissman Bernard E12,Major Michael B161314ORCID

Affiliation:

1. Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

2. Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA

3. Department of Otolaryngology/Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

4. Department of Genetics University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

5. UNC Neuroscience Center University of North Carolina at Chapel Hill Chapel Hill NC USA

6. Department of Pharmacology University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

7. Cancer Program Broad Institute of MIT and Harvard Cambridge MA USA

8. Marsico Lung Institute University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

9. University of Tennessee Health Science Center for Cancer Research, Department of Medicine, Division of Hematology and Oncology University of Tennessee Memphis TN USA

10. Department of Pharmaceutical Sciences, College of Pharmacy University of Tennessee Memphis TN USA

11. Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute North Carolina Central University Durham NC USA

12. Center for Esophageal Disease and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA

13. Department of Cell Biology and Physiology University of North Carolina at Chapel Hill School of Medicine Chapel Hill NC USA

14. Department of Cell Biology and Physiology Washington University St Louis MO USA

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

Research and Education Foundation of the American Head and Neck Society

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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