Shielding and nurturing: Fibronectin as a modulator of cancer drug resistance

Author:

Farooq Faizah1,Amin Asif1,Wani Umer Majeed1,Lone Asif2,Qadri Raies A.1ORCID

Affiliation:

1. Department of Biotechnology University of Kashmir Srinagar Jammu and Kashmir India

2. Department of Biochemistry Deshbandu College, University of Delhi Delhi India

Abstract

AbstractResistance to chemotherapy and targeted therapies constitute a common hallmark of most cancers and represent a dominant factor fostering tumor relapse and metastasis. Fibronectin, an abundant extracellular matrix glycoprotein, has long been proposed to play an important role in the pathobiology of cancer. Recent research has unraveled the role of Fibronectin in the onset of chemoresistance against a variety of antineoplastic drugs including DNA‐damaging agents, hormone receptor antagonists, tyrosine kinase inhibitors, microtubule destabilizing agents, etc. The current review summarizes the role played by Fibronectin in mediating drug resistance against diverse anticancer drugs. We have also discussed how the aberrant expression of Fibronectin drives the oncogenic signaling pathways ultimately leading to drug resistance through the inhibition of apoptosis, promotion of cancer cell growth and proliferation.

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

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