Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development

Author:

Natsuaki Yutaka1ORCID,Leynes Andrew2,Wangerin Kristen3,Hamdi Mahdjoub4,Rajagopal Abhejit5,Kinahan Paul E.6,Laforest Richard4,Larson Peder E. Z.5,Hope Thomas A.5,James Sara St.7

Affiliation:

1. Keck School of Medicine of USC, University of Southern California Los Angeles California USA

2. iSono Health Inc. South San Francisco California USA

3. GE Healthcare Waukesha Wisconsin USA

4. Washington University School of Medicine in St. Louis St. Louis Missouri USA

5. University of California, San Francisco San Francisco California USA

6. University of Washington Seattle Washington USA

7. University of Utah Salt Lake City Utah USA

Abstract

AbstractBackgroundIn modern positron emission tomography (PET) with multi‐modality imaging (e.g., PET/CT and PET/MR), the attenuation correction (AC) is the single largest correction factor for image reconstruction. One way to assess AC methods and other reconstruction parameters is to utilize software‐based simulation tools, such as a lesion insertion tool. Extensive validation of these simulation tools is required to ensure results of the study are clinically meaningful.PurposeTo evaluate different PET AC methods using a synthetic lesion insertion tool that simulates lesions in a patient cohort that has both PET/MR and PET/CT images. To further demonstrate how lesion insertion tool may be used to extend knowledge of PET reconstruction parameters, including but not limited to AC.MethodsLesion quantitation is compared using conventional Dixon‐based MR‐based AC (MRAC) to that of using CT‐based AC (CTAC, a “ground truth”). First, the pre‐existing lesions were simulated in a similar environment; a total of 71 lesions were identified in 18 pelvic PET/MR patient images acquired with a time‐of‐flight simultaneous PET/MR scanner, and matched lesions were inserted contralaterally on the same axial slice. Second, synthetic lesions were inserted into four anatomic target locations in a cohort of four patients who didn't have any observed clinical lesions in the pelvis.ResultsThe matched lesion insertions resulted in unity between the lesion error ratios (mean SUVs), demonstrating that the inserted lesions successfully simulated the original lesions. In the second study, the inserted lesions had distinct characteristics by target locations and demonstrated negative max‐SUV%diff trends for bone‐dominant sites across the patient cohort.ConclusionsThe current work demonstrates that the applied lesion insertion tool can simulate uptake in pelvic lesions and their expected SUV values, and that the lesion insertion tool can be extended to evaluate further PET reconstruction corrections and algorithms and their impact on quantitation accuracy and precision.

Funder

National Institutes of Health

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3