Large‐scale plasma proteomic profiling identifies a high‐performance biomarker panel for Alzheimer's disease screening and staging

Author:

Jiang Yuanbing1,Zhou Xiaopu123,Ip Fanny C.123,Chan Philip1,Chen Yu1234,Lai Nicole C.H.1,Cheung Kit1,Lo Ronnie M.N.1,Tong Estella P.S.1,Wong Bonnie W.Y.1,Chan Andrew L.T.5,Mok Vincent C.T.6,Kwok Timothy C.Y.7,Mok Kin Y.1289,Hardy John289,Zetterberg Henrik2891011,Fu Amy K.Y.123,Ip Nancy Y.123ORCID

Affiliation:

1. Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology Hong Kong China

2. Hong Kong Center for Neurodegenerative Diseases Hong Kong China

3. Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen–Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute Shenzhen China

4. The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen–Hong Kong Institute of Brain Science–Shenzhen Fundamental Research Institutions Shenzhen China

5. Divisions of Neurology and Geriatrics Department of Medicine Queen Elizabeth Hospital Hong Kong China

6. Gerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Neurology Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

7. Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Geriatrics Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

8. Department of Neurodegenerative Disease UCL Institute of Neurology London UK

9. UK Dementia Research Institute at UCL London UK

10. Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden

11. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

Funder

Innovation and Technology Commission

National Natural Science Foundation of China

Shenzhen Knowledge Innovation Program

Vetenskapsrådet

H2020 European Research Council

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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