Affiliation:
1. Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya Japan
2. Department of Pathology and Laboratory Medicine Nagoya University Graduate School of Medicine Nagoya Japan
3. Department of Endoscopy Nagoya University Hospital Nagoya Japan
Abstract
AbstractBackground/PurposeTo assess the diagnostic efficacy and safety of endoscopic ultrasound‐guided fine needle biopsy (EUS‐FNB) using a 19‐gauge Franseen needle for autoimmune pancreatitis (AIP).MethodsTwenty patients suspected of having type 1 AIP were prospectively enrolled and underwent EUS‐FNB with a 19‐gauge Franseen needle. Their data were compared with those of historical controls: a total of 29 type 1 AIP patients had EUS‐FNB with a 22‐gauge Franseen needle.ResultsSpecimens suitable for histological evaluation were obtained from 19 of the 20 patients (95%), and the median total tissue area was 11.9 mm2. The histological diagnosis rate of AIP was 65% (95% CI: 43.2%–82%). Adverse events were observed in three patients (15%), and a switch to 22‐gauge needles occurred during transduodenal puncture in two patients. Compared to those punctured with 22‐gauge needles, patients punctured with 19‐gauge needles had greater prevalence of each characteristic feature of lymphoplasmacytic sclerosing pancreatitis, but the difference was not statistically significant.ConclusionsEUS‐FNB using a 19‐gauge Franseen needle demonstrated favorable performance for the histological diagnosis of AIP and allowed for large tissue samples, potentially facilitating pathological diagnosis. However, during transduodenal puncture, maneuverability is reduced; therefore, the needle may need to be selected according to the puncture site.