1. a Department of Anesthesiology and Pain Medicine The Ottawa Hospital, Ottawa, Ontario, Canada
2. b Blueprint Translational Research Group, Clinical Epidemiology Program Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
3. c Regenerative Medicine Program Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
4. g Department of Cellular and Molecular Medicine University of Ottawa, Ottawa, Ontario, Canada
5. d Faculty of Medicine University of Ottawa, Ottawa, Ontario, Canada
6. e Division of Critical Care The Ottawa Hospital, Ottawa, Ontario, Canada
7. f Population Health Research Institute, David Braley Cardiac, Vascular, and Stroke Research Institute, Departments of Medicine and Research Methods, Evidence, and Impact McMaster University, Hamilton, Ontario, Canada
8. h Department of Anesthesia Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Department of Physiology, Toronto, Ontario, Canada
9. i Department of Medicine McMaster University, Hamilton, Ontario, Canada